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Trends Immunol. 2003 Apr;24(4):213-9.

Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm.

Author information

1
Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE113/RE216, Boston, MA 02115, USA. zchen@caregroup.harvard.edu

Abstract

The role of gammadelta T cells in adaptive immunity remains uncertain. Recent studies have demonstrated that a unique subset of gammadelta T cells in primates can mount adaptive immune responses during mycobacterial infections. This Review discusses notable similarities and differences in adaptive immune responses between non-peptide-specific gammadelta T cells and peptide-specific alphabeta T cells, and discusses both the molecular basis for gammadelta T-cell responses and potential functions of these enigmatic cells.

PMID:
12697454
PMCID:
PMC2869283
[Indexed for MEDLINE]
Free PMC Article

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