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Trends Immunol. 2003 Apr;24(4):165-8.

Suppression of antiviral responses by antibody-dependent enhancement of macrophage infection.

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Queensland Institute of Medical Research and the Australian Centre for International & Tropical Health & Nutrition, 300 Herston Road, Herston, Queensland 4029, Australia.


Antibody-dependent enhancement (ADE) of macrophage and monocyte infection has been demonstrated in vitro for some of the most deadly RNA viruses known. Recent evidence suggests that ADE-mediated ligation of Fc receptors might suppress host-cell antiviral gene expression by promoting early interleukin-10 (IL-10) secretion, resulting in the expression of suppressor-of-cytokine-signalling (SOCS) proteins and a Th2 bias. These findings provide potential new insights into how ADE might enhance viral infections and exacerbate disease.

[Indexed for MEDLINE]

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