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Trends Immunol. 2003 Apr;24(4):162-4.

Expression of CD94-NKG2A inhibitory receptor is restricted to a subset of CD8+ T cells.

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Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Sophia Antipolis 06 560, France.


Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-cell receptor (TCR) engagement, commitment to CD94-NKG2A expression is a clonal attribute. NKRs can therefore shape cytotoxic T-lymphocyte (CTL) responses and should be considered in designing vaccine therapies.

[Indexed for MEDLINE]

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