Format

Send to

Choose Destination
Trends Immunol. 2003 Apr;24(4):155-8.

Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules.

Author information

1
Institute of Experimental Dermatology, University of Muenster, Von-Esmarch-Str. 58, D-48149 Muenster, Germany.

Abstract

Three members of the S100 family of calcium-binding proteins comprise a new group of proinflammatory molecules released by phagocytes. A novel inflammatory syndrome defined by extraordinarily high expression of S100A8 and S100A9 confirmed recent observations in vitro demonstrating a role of these proteins during recruitment of leukocytes. S100A12 directly activates endothelial cells, mononuclear phagocytes and lymphocytes through interaction with the receptor for advanced glycation end products. Thus, these S100-proteins are attractive targets to modulate inflammation.

PMID:
12697438
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center