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Trends Immunol. 2003 Apr;24(4):155-8.

Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules.

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Institute of Experimental Dermatology, University of Muenster, Von-Esmarch-Str. 58, D-48149 Muenster, Germany.


Three members of the S100 family of calcium-binding proteins comprise a new group of proinflammatory molecules released by phagocytes. A novel inflammatory syndrome defined by extraordinarily high expression of S100A8 and S100A9 confirmed recent observations in vitro demonstrating a role of these proteins during recruitment of leukocytes. S100A12 directly activates endothelial cells, mononuclear phagocytes and lymphocytes through interaction with the receptor for advanced glycation end products. Thus, these S100-proteins are attractive targets to modulate inflammation.

[Indexed for MEDLINE]

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