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Biochim Biophys Acta. 2003 Apr 15;1626(1-3):102-5.

A heme-deficient strain of Escherichia coli has a three-base pair deletion in a "hotspot" in hemA.

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Department of Biology, City College, City University of New York, New York, NY 10031, USA.


The key regulatory step in heme biosynthesis in Escherichia coli is at the level of glutamyl-tRNA reductase (GTR), an enzyme which is encoded by hemA. A strain, HU227, with a spontaneous in-frame mutation in hemA has no GTR activity. The mutation is shown to be a three-base deletion at a "hotspot" in the gene. The amino acid sequence in this region is highly conserved.

[Indexed for MEDLINE]

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