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Haemophilia. 2003 May;9(3):269-71.

Management of haemophilia B inhibitor patients with anaphylactic reactions to FIX concentrates.

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Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.


Allergic reactions to concentrates containing factor IX (FIX) are serious complications in the treatment of haemophilia B patients with inhibitor. We have established a therapeutic protocol for such cases using an initial skin test followed by step-wise infusions of FIX concentrates under hydrocortisone cover. We have successfully treated three patients whose treatment with FIX had been suspended.

[Indexed for MEDLINE]

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