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J Hered. 2003 Jan-Feb;94(1):65-8.

Two cases of infertile bitches with 78,XX/77,X mosaic karyotype: a need for cytogenetic evaluation of dogs with reproductive disorders.

Author information

1
Department of Genetics and Animal Breeding, August Cieszkowski Agricultural University of Poznán, Wolynska 33, 60-637 Poznán, Poland. switonsk@jay.au.poznan.pl

Abstract

A mosaic karyotype 78,XX/77,X was found in two infertile purebred dogs. Cytogenetic investigations were carried out on a large number of metaphase spreads (220 and 473) with the use of conventional Giemsa staining, C-banding, and chromosome painting approaches. The frequencies of the monosomic spreads (77,X) were low: 5.3% and 5.6%. We recommend that at least 90 metaphase spreads be analyzed to allow possible detection of low-level XX/X mosaicism, and we discuss the need for cytogenetic evaluation of dogs with reproductive disorders.

PMID:
12692164
[Indexed for MEDLINE]

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