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Neuron. 2003 Apr 10;38(1):13-6.

Parkin: a multipurpose neuroprotective agent?

Author information

1
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Room 514, Boston, Massachusetts 02115, USA. mel_feany@hms.harvard.edu

Abstract

An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal dysfunction, Pael-R accumulation, and kainate-induced excitotoxicity. These findings suggest a central role for parkin in maintaining dopaminergic neuronal integrity and strengthen the link between AR-JP and the more common sporadic form of Parkinson's disease.

PMID:
12691660
DOI:
10.1016/s0896-6273(03)00201-0
[Indexed for MEDLINE]
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