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Dev Cell. 2003 Apr;4(4):442-4.

All roads lead to ATF4.

Author information

1
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

Abstract

Multiple intracellular stress pathways converge on a single event--phosphorylation of the translation initiation factor eIF2alpha and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.

PMID:
12689582
DOI:
10.1016/s1534-5807(03)00100-x
[Indexed for MEDLINE]
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