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Clin Infect Dis. 2003 Apr 15;36(8):1067-9. Epub 2003 Apr 4.

Decrease in human immunodeficiency virus type 1 load during acute dengue fever.

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  • 1Department of Retrovirology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.


Rather than the expected increase in human immunodeficiency virus type 1 (HIV-1) load, there was transient suppression of HIV-1 replication during acute dengue infection in a 29-year-old Thai woman. Acute-phase (but not convalescent-phase) serum samples obtained from an HIV-1-uninfected patient with dengue fever reduced HIV-1 infectivity, as determined by a peripheral blood mononuclear cell assay, suggesting the possibility that HIV-1 replication is suppressed during acute dengue fever, as occurs during some cases of scrub typhus infection and measles.

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