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Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4945-50. Epub 2003 Apr 8.

A network of rice genes associated with stress response and seed development.

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Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA.


We used a systematic approach to build a network of genes associated with developmental and stress responses in rice by identifying interaction domains for 200 proteins from stressed and developing tissues, by measuring the associated gene expression changes in different tissues exposed to a variety of environmental, biological, and chemical stress treatments, and by localizing the cognate genes to regions of stress-tolerance trait genetic loci. The integrated data set suggests that similar genes respond to environmental cues and stresses, and some may also regulate development. We demonstrate that the data can be used to correctly predict gene function in monocots and dicots. As a result, we have identified five genes that contribute to disease resistance in Arabidopsis.

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