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Ann Epidemiol. 2003 Apr;13(4):252-60.

Birth cohort effects in multiple sclerosis.

Author information

1
Neuroepidemiology Unit, Division of Neurology, Karolinska Institute, Huddinge University Hospital, S-141 86, Huddinge, Sweden. Ya-Ping.Jin@neurotec.ki.se

Abstract

PURPOSE:

To identify potential birth cohort effects in multiple sclerosis in Sweden and particularly in Stockholm county.

METHODS:

Data on multiple causes of death from multiple sclerosis during 1962 to 1995 in Sweden and 1968 to 1995 in Stockholm county were analyzed using age-period-cohort models and curvature.

RESULTS:

Mortality from multiple sclerosis was higher in Sweden than in Stockholm county, with stable time trends, slight period effects and marked age effects. Cohorts born before or after a central period, from 1910 through 1930, registered lower mortality. A periodic wave-form mortality pattern was identified, following a 5-to-6-year cycle for cohorts born before 1925 both in and outside Stockholm county, and changing to longer or irregular cycles for cohorts born after 1930.

CONCLUSIONS:

Although methodological constraints inducing the saw-tooth pattern cannot be excluded, these results are consistent with etiologic hypotheses claiming a role for environmental factors in multiple sclerosis.

PMID:
12684191
[Indexed for MEDLINE]
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