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Trends Genet. 2003 Apr;19(4):207-16.

Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.

Author information

  • 1Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14623, USA.

Erratum in

  • Trends Genet. 2003 Jul;19(7):369.


Alteration of mRNA sequence through base modification mRNA editing frequently generates protein diversity. Several proteins have been identified as being similar to C-to-U mRNA editing enzymes based on their structural domains and the occurrence of a catalytic domain characteristic of cytidine deaminases. In light of the hypothesis that these proteins might represent novel mRNA editing systems that could affect proteome diversity, we consider their structure, expression and relevance to biomedically significant processes or pathologies.

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