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J Biomed Opt. 2003 Apr;8(2):260-3.

Speckle reduction in optical coherence tomography by "path length encoded" angular compounding.

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  • 1Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, BAR 703, Boston, Massachusetts 02114, USA.

Abstract

Speckle, the dominant factor reducing image quality in optical coherence tomography (OCT), limits the ability to identify cellular structures that are essential for diagnosis of a variety of diseases. We describe a new high-speed method for implementing angular compounding by path length encoding (ACPE) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and requires minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased SNR that correlates well with theory.

PMID:
12683852
DOI:
10.1117/1.1559060
[PubMed - indexed for MEDLINE]
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