Post-transplant lymphoproliferative disorder (PTLD) is a recognized complication of solid-organ transplantation. We describe a 56-year-old man with end-stage idiopathic pulmonary fibrosis who underwent right-sided single-lung transplantation and who had biopsy-proven PTLD involving the main bronchi 3 months later. The lesions recurred despite endobronchial electrosurgery and systemic therapy with interferon for 3 months. Interferon was deceased and anti-CD20 therapy and photodynamic therapy were performed concurrently using flexible bronchoscopy. The subsequent follow-up endobronchial biopsy specimen results were negative for PTLD. This case is the first reported use of photodynamic therapy combined with anti-CD20 for treating PTLD. Endobronchial PTLD is a rare complication of lung transplantation and can be managed successfully with photodynamic therapy.