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Anticancer Res. 2003 Jan-Feb;23(1A):305-8.

Is DD3 a new prostate-specific gene?

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  • 1Department of Experimental Medicine and Pathology, Section of Pathologic Anatomy, University La Sapienza of Rome, Viale Regina Elena 324, 00161 Rome, Italy.


The search for new and more specific molecular markers of prostatic cancers has led, in recent years, to the identification of the DD3 gene. Using reverse transcription (RT)-PCR, we investigated DD3 gene expression in human cell lines, in blood samples from healthy men and women donors and in various neoplastic and non-neoplastic tissues from the prostate and other organs. Whereas RT-PCR analysis using primers that amplified the region spanning exons 1 and 3 yielded DD3 gene expression in all samples examined, a primer downstream to exon 4 detected the expected size DD3 band only in benign and malignant prostatic tissues. These findings indicate that the only prostate specific region of DD3 is exon 4.

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