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Curr Med Chem. 2003 Jun;10(12):1051-64.

Emerging understanding of the advantage of small molecules such as hydroxypyridinones in the treatment of iron overload.

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  • 1Department of Pharmacy, King's College London, UK.


Deferiprone, a hydroxypyridin-4-one, is effective at facilitating iron removal from iron overloaded patients, when administered orally. Some problems associated with deferiprone are discussed. Hydroxypyridinone analogues with improved distribution, metabolism and affinity for iron are described. In particular the "high pFe(3+)" hydroxypyridin-4-ones possess considerable clinical potential.

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