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Curr Biol. 2003 Apr 1;13(7):R273-5.

Notch signaling: endocytosis makes delta signal better.

Author information

1
CNRS UMR 8542, Département de Biologie, Ecole Normale Supérieure, 46 rue d'Ulm, 75230, Paris cedex, France.

Abstract

Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.

PMID:
12676105
DOI:
10.1016/s0960-9822(03)00199-4
[Indexed for MEDLINE]
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