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Curr Opin Genet Dev. 2003 Apr;13(2):199-206.

Evolution of transcription factor function.

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Section of Cell & Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA.


Functional assays in Drosophila melanogaster with orthologous transcription factors from other species suggest that changes in the protein-coding sequence may play a larger role in the evolution of transcription factor pathways than was previously believed. Interestingly, recent studies provide evidence that changes in transcription factor protein sequence can affect the regulation of only a subset of target genes, even in the same cells of a developing animal.

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