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Curr Opin Genet Dev. 2003 Apr;13(2):161-9.

Dosage compensation: an intertwined world of RNA and chromatin remodelling.

Author information

1
European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany. akhtar@embl-heidelberg.de

Abstract

Dosage compensation mechanisms in flies and mammals provide an exquisite example of chromatin associated RNAs in chromosome-wide transcription regulation. Recent progress shows that chromatin modifications are also closely linked to these processes. Concerted action of the RNA/chromatin-modifying enzymes may play a crucial role in determining transcriptional output. Furthermore, non-coding RNAs appear to play a dual role, being targeting modules as well as encoding for target sites for complex recognition.

PMID:
12672493
DOI:
10.1016/s0959-437x(03)00016-9
[Indexed for MEDLINE]

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