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Curr Opin Genet Dev. 2003 Apr;13(2):154-60.

Functional consequences of histone modifications.

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Department of Microbiology, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA.


Covalent modifications of the histone proteins have well-known roles in gene expression. Experiments reported during the past year have extended this paradigm to include roles for histone acetylation and phosphorylation in DNA double-strand break repair. In addition, new results now provide a definitive example of an acetylation histone code, whereas others reveal the workings of a charge patch mechanism. Finally, exciting research has identified new modifications, complex modification cascades, and functional links to DNA methylation and RNA interference pathways.

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