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J Med Chem. 2003 Apr 10;46(8):1546-53.

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.

Author information

1
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Belgium.

Abstract

The synthesis of a series of N-aminoimidazoles (NAIMs) with an uncommon spectrum of antiretroviral activity is described. From a group of 60 closely related molecules, we were able to subdivide the molecules in different groups based on their anti-HIV and anti-SIV activity in vitro: (i) molecules acting on a new, immediate postintegration step, (ii) molecules acting on both postintegration and HIV-1 reverse transcriptase (RT) as NNRTI, and (iii) molecules that mainly act at the HIV-1 RT according to an NNRTI-type mode of action.

PMID:
12672256
DOI:
10.1021/jm0211117
[Indexed for MEDLINE]

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