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Phytother Res. 2003 Mar;17(3):240-3.

Anti-allergic effect of Perilla frutescens and its active constituents.

Author information

1
Department of Kampo Medicinal Sciences, Hokkaido College of Pharmacy, Katsuraoka, Otaru, Japan. makino@hokuyakudai.ac.jp

Abstract

The leaves of Perilla frutescens Britton (Labiatae) are one of the most popular garnishes in Japan, used as an antidote for fi sh and crab meat allergy or as a food colorant. The present study was conducted to evaluate its anti-allergic effect and to identify its active constituents using mice ear-passive cutaneous anaphylaxis (PCA)-reaction. 48 h after the cutaneous injection of anti-ovalbumin serum into the ears of mice, ovalbumin and evansblue dye were intravenously injected. Perilla was extracted with boiling water, and intraperitoneally injected 15 min before ovalbumin-treatment. Thirty min after ovalbumin-treatment, the ears were removed and the colorant in the ear was colorimetrically quantitated. Perilla extract significantly suppressed the PCA-reaction, which was brought about by rosmarinic acid with a partial contribution from some macromolecular compounds. The anti-allergic titer of rosmarinic acid was more effective than tranilast, which is a modern anti-allergic drug. Perilla and rosmarinic acid are potentially promising agents for the treatment of allergic diseases.

PMID:
12672153
DOI:
10.1002/ptr.1115
[Indexed for MEDLINE]

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