Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2003 Apr;4(4):276-84.

Histone acetylation and deacetylation in yeast.

Author information

1
Department of Biological Chemistry, University of California School of Medicine, Los Angeles, California 90095, USA.

Abstract

Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an untargeted and global manner, by affecting most nucleosomes. Recently, new roles for histone acetylation have been uncovered, not only in transcription but also in DNA replication, repair and heterochromatin formation. Interestingly, specific acetylatable lysines can function as binding sites for regulatory factors. Moreover, histone deacetylation is not only repressive but can be required for gene activity.

PMID:
12671650
DOI:
10.1038/nrm1075
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center