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Curr Opin Drug Discov Devel. 2003 Mar;6(2):218-23.

Zebrafish: from disease modeling to drug discovery.

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Zygogen LLC, 520 Kell Hall, 24 Peachtree Center Avenue, Atlanta, GA 30303, USA.


The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding to include human disease. Zebrafish models based on known disease mechanisms have been developed in several therapeutic areas, including blood diseases, diabetes, muscular dystrophy, neurodegenerative disease, angiogenesis and lipid metabolism. This review summarizes recent progress in disease model development, and outlines the potential of zebrafish to contribute to drug discovery through the identification of novel drug targets, validation of those targets and screening for new therapeutic compounds.

[Indexed for MEDLINE]

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