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Nat Rev Drug Discov. 2003 Apr;2(4):278-88.

Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets.

Author information

1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachussets 02115, USA. don_coen@hms.harvard.edu

Abstract

In the absence of effective vaccines to control herpesvirus infections, nucleosidic antiviral drugs have been the mainstay of clinical treatment since their development in the late 1970s. However, given the drawbacks of these drugs, including the increasing emergence of drug-resistant clinical isolates, new strategies for treating herpesvirus infections are warranted. A range of promising new drugs with novel molecular targets has been developed, but will they cure latent infections?

PMID:
12669027
DOI:
10.1038/nrd1065
[Indexed for MEDLINE]

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