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Nat Rev Immunol. 2003 Apr;3(4):304-16.

Immune functions encoded by the natural killer gene complex.

Author information

1
Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Barnes-Jewish Hospital and Washington University School of Medicine, Box 8045, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. yokoyama@imgate.wustl.edu

Abstract

There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.

PMID:
12669021
DOI:
10.1038/nri1055
[Indexed for MEDLINE]

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