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Bioorg Med Chem Lett. 2003 Apr 17;13(8):1437-9.

Novel openers of Ca2+-dependent large-conductance potassium channels: symmetrical pharmacophore and electrophysiological evaluation of bisphenols.

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1
Computer-Assisted Drug Design, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. yi.li@bms.com

Abstract

Electrophysiological evaluation of symmetrical analogues of the known maxi-K opener NS-004 (1) led to the discovery of bisphenols 2a, 3a and 4a as openers of cloned maxi-K channels expressed in oocytes.

PMID:
12668007
[Indexed for MEDLINE]
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