Send to

Choose Destination
See comment in PubMed Commons below
Virology. 2003 Mar 1;307(1):37-44.

HIV-1 infection in peripheral blood lymphocytes (PBLs) exposed to alcohol.

Author information

  • 1Department of Oral & Maxillofacial Surgery, Charles R. Drew University of Medicine & Science, Hawkins Building, Room 3067, 1731 East 120th Street, Los Angeles, CA 90059, USA.


Epidemiological and in vitro studies have implied that heavy alcohol consumption may increase an individual's risk of HIV-1 infection. To examine the role of alcohol in direct infection of T-cells, viral reverse transcripts and HIV-1 receptor expression were examined in infected peripheral blood lymphocytes (PBLs) pretreated with alcohol. PCR results showed that alcohol increased HIV-1 DNA in PBLs by at least 10-fold. Alcohol enhanced the expression of the CXCR4 chemokine co-receptor but not the major HIV-1 CD4 receptor. Pretreatment with alcohol was also associated with increased intracellular cAMP. Thus, alcohol may facilitate enhanced viral infection by increasing the availability of HIV-1 co-receptor. This effect is associated with increases in intracellular cAMP.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center