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Virology. 2003 Mar 15;307(2):255-65.

Proteomics computational analyses suggest that hepatitis C virus E1 and pestivirus E2 envelope glycoproteins are truncated class II fusion proteins.

Author information

1
Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA. rfgarry@tulane.edu

Abstract

Class II fusion proteins encoded by tick-borne encephalitis virus (TBEV), dengue virus, and Semliki Forest virus have a fusion peptide located at the end of a rod-like molecule comprised of three antiparallel beta sheet domains. Proteomics computational analyses suggest that hepatitis C virus (HCV) envelope glycoprotein E1 and pestivirus envelope glycoprotein E2 are truncated class II fusion proteins. Similarities were also detected between the receptor-binding portion of TBEV E and HCV E2, and between TBEV small membrane protein precursor prM and pestivirus E1. The proposed models of Flaviviridae envelope proteins can facilitate drug and vaccine development.

PMID:
12667795
DOI:
10.1016/s0042-6822(02)00065-x
[Indexed for MEDLINE]
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