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Mol Cell. 2003 Mar;11(3):557-69.

The making of the mitotic chromosome: modern insights into classical questions.

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Division of Gene Regulation and Expression, University of Dundee, DD1 5EH, Dundee, United Kingdom.


The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.

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