The phase diagram for the ternary system propylene glycol-sodium chloride-water and their application to platelet cryopreservation

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003 Feb;11(1):92-5.

Abstract

In order to acquire freezing model of the cryopretective solution (NaCl-propylene glycol-water ternary system) for platelet, the melting points (T(f)) of this cryopretective solutions with different solute concentration and different ratio of PG mass to NaCl mass were measured by using a differential scanning calorimeter (DSC), and these experimental data were fitting by computer. An empirical equation was derived which characterized the Tf as a function of the solute concentration and the ratio of PG mass to NaCl mass inside this solution. It was concluded that the equilibrium freezing model for human platelets in this system could be used to instruct platelet cryopreserving techniques.

MeSH terms

  • Blood Platelets* / drug effects
  • Cryopreservation / methods*
  • Cryoprotective Agents / chemistry*
  • Cryoprotective Agents / pharmacology
  • Humans
  • Models, Chemical
  • Organ Preservation Solutions / chemistry*
  • Organ Preservation Solutions / pharmacology
  • Propylene Glycol / chemistry
  • Propylene Glycol / pharmacology
  • Sodium Chloride / chemistry
  • Sodium Chloride / pharmacology
  • Temperature
  • Water / chemistry
  • Water / pharmacology

Substances

  • Cryoprotective Agents
  • Organ Preservation Solutions
  • Water
  • Sodium Chloride
  • Propylene Glycol