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J Biol Chem. 2003 May 30;278(22):19904-8. Epub 2003 Mar 27.

Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I.

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1
Roy M. and Phyllis Gough Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA. jyoung@bcm.tmc.edu

Abstract

The finite proliferative potential of normal human fibroblasts can be overcome, a process commonly called immortalization, by the introduction of the catalytic subunit of human telomerase. In contrast to malignant transformation, the pattern of gene expression remains largely unmodified in telomerase-induced immortalization. Here we show evidence that suggests that the maintenance of a "young" pattern of gene expression by telomerization is mediated, at least in part, by a novel function of human telomerase that involves regulation of DNA methyltransferase I gene expression.

PMID:
12665523
DOI:
10.1074/jbc.M301685200
[Indexed for MEDLINE]
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