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IEEE Trans Biomed Eng. 2003 Feb;50(2):255-8.

Two multichannel integrated circuits for neural recording and signal processing.

Author information

  • 1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. io@duke.edu

Abstract

We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. Device B is a 16-channel two-stage analog signal processor with differential amplification and high-pass filtering. It features selectable gains of 250 and 500 V/V as well as reference channel selection. The resulting amplifiers on Device A had a mean gain of 1.99 V/V with an equivalent input noise of 10 microV(rms). Those on Device B had mean gains of 53.4 and 47.4 dB with a high-pass filter pole at 211 Hz and an equivalent input noise of 4.4 microV(rms). Both devices were tested in vivo with electrode arrays implanted in the somatosensory cortex.

PMID:
12665041
DOI:
10.1109/TBME.2002.807643
[PubMed - indexed for MEDLINE]
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