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Int J Obes Relat Metab Disord. 2003 Apr;27(4):457-62.

Leptin does not respond to 48 h fat deposition or mobilization in women.

Author information

1
MRC Dunn Clinical Nutrition Centre, Cambridge, UK. prm13@cam.ac.uk

Abstract

OBJECTIVE:

To test the hypothesis that acute responses of plasma leptin concentration to energy balance manipulation are mediated by fat flux.

DESIGN:

Ten healthy women aged 31-63 y, mass 48-113.5 kg, fat mass 8.5-62.5 kg, were studied for 3 days in a whole-body calorimeter on two occasions. After a control day (D1) during which energy balance was maintained, diet was manipulated to induce fat deposition (FD) or mobilization (FM) of 50 g/day for 2 days (D2 & D3). A difference totalling of 194+/-18.6 g fat was achieved between manipulations without significant effects on carbohydrate or protein balance. Fasting plasma leptin was measured on D2 and D4.

RESULTS:

After the control day plasma leptin concentration averaged 19.01+/-9.8 ng/ml, and was found to be linearly related to body fat mass. After 2 days manipulation of fat balance, leptin concentrations were 21.4+/-10.3 ng/ml (FD) and 21.2+/-11.3 ng/ml (FM). There was no significant difference between treatments in either control day or postmanipulation leptin concentrations, nor did the treatments induce any differences in glucose or insulin concentration responses.

CONCLUSION:

Although in states of energy balance leptin concentration is linearly related to fat mass, acute modulation of leptin concentration during energy imbalance is not mediated by fat flux.

PMID:
12664079
DOI:
10.1038/sj.ijo.0802252
[Indexed for MEDLINE]

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