Format

Send to

Choose Destination
See comment in PubMed Commons below
J Org Chem. 2003 Apr 4;68(7):2952-5.

Efficient synthesis of an enantiopure beta-lactam as an advanced precursor of thrombin and tryptase inhibitors.

Author information

1
Dipartimento di Chimica Organica e Industriale and CNR-ISTM, Universita' degli Studi di Milano, Via Golgi 19 - 20133 Milano, Italy maurizio.benaglia@unimi.it

Abstract

A new and efficient synthesis of a beta-lactam that is an advanced precursor of inhibitors of thrombin and tryptase is reported. The reaction sequence is based on the use of an inexpensive enantiomerically pure starting material and is designed to allow access to both enantiomers of the target molecules by epimerization of a side-product obtained along the synthesis. An improved procedure for the epimerization step that takes advantage of the use of a polymer-supported and recyclable phase-transfer catalyst is described.

PMID:
12662075
DOI:
10.1021/jo020617u
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center