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Genes Chromosomes Cancer. 2003 May;37(1):29-35.

Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.

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Abteilung Tumorgenetik, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany.


At present, there is conflicting evidence whether microsatellite instability (MSI) plays a role in the pathogenesis of breast cancer. Here we describe for the first time an MSI(+) phenotype in two breast cancer cell lines, CAL51 and MT-3, resembling that observed in colorectal cancers. These cell lines are characterized by near-diploid and hyperdiploid karyotypes, respectively. We detected MSI in these cell lines within two non-coding (BAT-25 and BAT-26) and within coding repeat sequences of genes known to be mutated in MSI(+) cancer (TGFBR2, IGF2R, BAX). We provide evidence that the inactivation of MMR genes is responsible for MSI in these cell lines.

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