Format

Send to

Choose Destination
See comment in PubMed Commons below
EMBO J. 2003 Apr 1;22(7):1588-98.

Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast.

Author information

1
Institut Curie-CNRS UMR2027, Bât. 110, Centre Universitaire, 91405 Orsay, France.

Abstract

Ssu72 is an essential yeast protein that is involved in transcription. It physically interacts with transcription initiation and termination complexes. In this report, we provide evidence that Ssu72 is a phosphatase that physically interacts with the CTD kinase Kin28 and functionally interacts with the CTD phosphatase Fcp1. A genome-wide expression analysis of mutant ssu72-ts69 during growth in complete medium revealed a number of defects, including the accumulation of a limited number of mRNAs and the read-through transcription of small nucleolar RNAs and of some mRNAs. We hypothesize that Ssu72 plays a key role in the transcription termination of certain transcripts, possibly by promoting RNA polymerase pausing and release. The possibility that the CTD of the largest subunit of RNA polymerase II is a substrate of Ssu72 is discussed.

PMID:
12660165
PMCID:
PMC152886
DOI:
10.1093/emboj/cdg141
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center