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Bioorg Med Chem. 2003 Apr 17;11(8):1873-81.

Synthesis of potent oxindole CDK2 inhibitors.

Author information

1
Hoffmann-La Roche Inc., 340 Kingsland str., Nutley, NJ 07110-1199, USA. apostolos.dermatakis@roche.com

Abstract

A series of oxindole CDK2 inhibitors was synthesized. These novel analogues have a saturated monosubstituted cyclic moiety at their C-4 position that mimics the ribofuranoside of ATP. This substitution afforded agents with increased potency relative to the parent indolinone and nanomolar range IC(50) against the CDK2 enzyme and two cancer cell lines.

PMID:
12659774
DOI:
10.1016/s0968-0896(03)00036-1
[Indexed for MEDLINE]

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