Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke

J Hanaway; R Torack; A P Fletcher; W M Landau

doi:10.1161/01.str.7.2.143

Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke

Stroke. 1976 Mar-Apr;7(2):143-6. doi: 10.1161/01.str.7.2.143.

Authors

J Hanaway, R Torack, A P Fletcher, W M Landau

PMID: 1265806
DOI: 10.1161/01.str.7.2.143

Abstract

Four patients undergoing urokinase infusion therapy for acute occlusive cerebrovascular disease had intracerebral hemorrhage in the ischemic hemisphere. Three patients died during the acute phase of their illness and an autopsy was performed on two. The pathogenesis of cerebral bleeding in these case reports is discussed.

MeSH terms

Aged
Brain / blood supply
Brain / pathology
Cerebral Hemorrhage / chemically induced*
Cerebrovascular Disorders / drug therapy*
Cerebrovascular Disorders / pathology
Endopeptidases / adverse effects*
Female
Humans
Ischemia / drug therapy
Male
Urokinase-Type Plasminogen Activator / adverse effects*

Substances

Endopeptidases
Urokinase-Type Plasminogen Activator