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Bioorg Med Chem Lett. 2003 Apr 7;13(7):1325-8.

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.

Author information

1
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park 60064-6123, USA. ramin.fagih@abbott.com

Abstract

Novel 4'-[(NR1R2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H(3) receptors and selected examples such as A-349821 showed functional antagonism of H(3) receptors in vitro and in a mouse dipsogenia model.

PMID:
12657274
DOI:
10.1016/s0960-894x(03)00118-5
[Indexed for MEDLINE]

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