Format

Send to

Choose Destination
J Gen Virol. 2003 Apr;84(Pt 4):837-44.

Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype.

Author information

1
Department of Chemistry and Biomedical Sciences, University of Kalmar, S-391 82 Kalmar, Sweden.

Abstract

Ljungan virus (LV) is a suspected human pathogen recently isolated from bank voles in Sweden. This study describes the genetic characterization of a virus, M1146, which was isolated in 1962 from another vole species (Microtus montanus), trapped in Oregon, USA. Based on antigenic properties, M1146 was postulated previously as a putative member of the family PICORNAVIRIDAE: The near complete genomic sequence verifies that M1146 is a member of the Picornaviridae, most closely related to LVs isolated in Sweden. The strain M1146 possesses typical LV genomic organization, including a cluster of two 2A homologues. There are significant differences throughout the capsid protein region, while the non-structural region of M1146 is closely related to the Swedish LV genomes. Genetic and phylogenetic analyses show that M1146 represents a new genotype within the distinct LV cluster. Isolation of LV from both Swedish and American voles trapped over a period of 30 years suggests a continuous worldwide presence.

PMID:
12655084
DOI:
10.1099/vir.0.18792-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Ingenta plc
Loading ...
Support Center