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Neurology. 2003 Mar 25;60(6):1020-2.

Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation.

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Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.


The authors searched for mutations in the beta-amyloid precursor protein in a Spanish family with a hereditary syndrome of hemorrhagic stroke, dementia, leukoencephalopathy, and occipital calcifications. DNA from two affected members demonstrated the Iowa amyloid precursor protein mutation previously identified as a cause of severe amyloid angiopathy without hemorrhagic stroke. These data point to other genetic or environmental factors that may determine the occurrence of symptomatic hemorrhage in amyloid angiopathy.

[Indexed for MEDLINE]

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