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Cell. 2003 Mar 21;112(6):737-40.

Variation on an Src-like theme.

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Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.


The modularity of protein architecture and the diversity of protein domains hint at a vast combinatorial richness. But evolution appears to have been relatively conservative about selecting new combinations. When a particular grouping of domains within a polypeptide chain can perform a concerted function, that combination tends to reappear in multiple genomic contexts. In other words, once a molecular solution to a functional problem has emerged, it is reused rather than reinvented.

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