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Cell. 2003 Mar 21;112(6):737-40.

Variation on an Src-like theme.

Author information

1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA. harrison@crystal.harvard.edu

Abstract

The modularity of protein architecture and the diversity of protein domains hint at a vast combinatorial richness. But evolution appears to have been relatively conservative about selecting new combinations. When a particular grouping of domains within a polypeptide chain can perform a concerted function, that combination tends to reappear in multiple genomic contexts. In other words, once a molecular solution to a functional problem has emerged, it is reused rather than reinvented.

PMID:
12654240
[Indexed for MEDLINE]
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