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Ai Zheng. 2003 Mar;22(3):328-30.

[Interactive pathway of ARF-mdm2-p53].

[Article in Chinese]

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Department of Pathology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, P.R. China.


The inhibitor of cyclin-dependent kinase 4-p16INK4 alpha and its alterative reading frame (ARF)-INK4/ARF gene locates at CDKN2A locus of human chromosome 9p21. This locus encodes two overlapped genes: ARF gene and p16INK4 alpha. The amino acid sequences of two genes are completely different because they are encoded by alternative reading frames. ARF participates in the regulation of mdm2-p53 pathway by mdm2. Recent studies showed that ARF gene may play a role in tumorigenesis; the ARF gene promoter hypermethylation may be the principal mechanism in the inactivation of this gene. Here is a review of ARF-mdm2-p53 interacting pathway.

[Indexed for MEDLINE]

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