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Di Yi Jun Yi Da Xue Xue Bao. 2003 Mar;23(3):239-41.

Effect of Angelica sinensis (Oliv.) on melanocytic proliferation, melanin synthesis and tyrosinase activity in vitro.

Author information

1
Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China.

Abstract

OBJECTIVE:

To investigate the effects of Angelica sinensis (Oliv.) on melanocytes and tyrosinase activity.

METHODS:

MTT method and cleavage by NaOH were employed to measure the proliferation and melanin synthesis of melanocytes, respectively. Tyrasinase activity assessment was performed by measuring the rate of oxidation of DL-dopa.

RESULTS:

Angelica sinensis (Oliv.) was found to promote melanocytic proliferation (P < 0.05), resulting in a statistically significant increase in the cell counts (P < 0.05). It also enhanced melanin synthesis (P < 0.05) and tryosinase activity (P < 0.05) of the melanocytes, and the most potent effects were achieved at the concentration of 1 g/L (P < 0.05).

CONCLUSION:

Angelica sinensis (Oliv.) promotes melanocytic proliferation, melanin synthesis and tyrosinase activity, which may be the mechanism for validating its clinical use in the treatment of skin pigmentation.

PMID:
12651240
[Indexed for MEDLINE]

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