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Cytokine Growth Factor Rev. 2003 Apr;14(2):91-8.

Novel PDGF family members: PDGF-C and PDGF-D.

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Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, S-171 77, Stockholm, Sweden.


Platelet-derived growth factors (PDGFs) were discovered almost two decades ago. The classical PDGF polypeptide chains, PDGF-A and PDGF-B, are well studied and they regulate a number of physiological and pathophysiological processes in many types of mesenchymal cells via two receptor tyrosine kinases, PDGF receptors alpha and beta. Recently, two additional PDGF polypeptide chains were discovered, namely PDGF-C and PDGF-D. The discovery of two additional ligands for the two PDGF receptors suggests that PDGF-mediated signaling is more complex than previously anticipated.

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