Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2003 Mar 21;299(5614):1898-902.

Discrete coding of reward probability and uncertainty by dopamine neurons.

Author information

1
Institute of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland. cdf28@cam.ac.uk

Abstract

Uncertainty is critical in the measure of information and in assessing the accuracy of predictions. It is determined by probability P, being maximal at P = 0.5 and decreasing at higher and lower probabilities. Using distinct stimuli to indicate the probability of reward, we found that the phasic activation of dopamine neurons varied monotonically across the full range of probabilities, supporting past claims that this response codes the discrepancy between predicted and actual reward. In contrast, a previously unobserved response covaried with uncertainty and consisted of a gradual increase in activity until the potential time of reward. The coding of uncertainty suggests a possible role for dopamine signals in attention-based learning and risk-taking behavior.

Comment in

PMID:
12649484
DOI:
10.1126/science.1077349
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center