Format

Send to

Choose Destination
Trends Microbiol. 2003 Mar;11(3):115-7.

Enterobacterial adhesins and the case for studying SNPs in bacteria.

Author information

1
Division of Infectious Disease, Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA.

Abstract

Single-nucleotide polymorphisms (SNPs) in structural genes can have a dramatic effect on the biology of whole organisms, from bacteria and viruses to mammals. Here, we underscore the importance of SNPs in bacterial genes that contribute to the ability of pathogens to cause disease. SNPs that confer an adaptive advantage for bacterial pathogens have been discovered in the genes encoding the FimH and Dr adhesins of Escherichia coli and, most recently, Salmonella enterica sv. Typhimurium FimH.

PMID:
12648942
DOI:
10.1016/s0966-842x(03)00010-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center