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Trends Microbiol. 2003 Mar;11(3):105-8.

Hypervirulence and pathogen fitness.

Author information

1
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095-1747, USA.

Abstract

Historically, pathogenesis research has focused on the identification and characterization of virulence factors. More recently, 'anti-virulence' genes have been discovered. Mutations in these loci result in a hypervirulent phenotype, as measured by a lower lethal dose, a colonization advantage, reduced clearance or decreased survival time of the host. If these genes function to reduce pathogen virulence, why have they been retained? Multiple hypotheses have been offered to explain this phenomenon.

PMID:
12648937
DOI:
10.1016/s0966-842x(03)00007-6
[Indexed for MEDLINE]

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